Pathos

Unveiling the Transcription Factor Circuitry: Resetting the Clock of Life in Early Embryonic Development

Pathos /

Thoughts on Professor Wei Xie’s seminar “Decoding the transcription circuitry when life begins” Deciphering the molecular beginnings of life is fraught with challenges, primarily due to the scarcity of embryonic material available for research. Prof. Wei Xie’s team has advanced our understanding by developing ultra-sensitive chromatin analysis technologies, enabling them to map the chromatin landscape […]

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Epigenetics in the Nervous System: Development and Disease Conference 2022

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In June 2022, I had the opportunity to attend the ‘Epigenetics in the Nervous System: development and disease’ conference jointly organized by Gonçalo Castelo-Branco, Ana Pombo and Abcam in MDC, Berlin. As the first in-person conference since the start of the pandemic for many of the attendees, the excitement in the air was palpable. This was especially

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Completing the incomplete human genome: a 20-year quest

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Missing puzzles of the human genome The first draft of the reference human genome was released more than 20 years ago (Lander et al., 2001; Venter et al., 2001). Since its completion, the reference human genome has undergone major rounds of amendments to incorporate newly assembled sequences and correct alignment errors. The latest patch, GRCh38.p13/hg38, represents

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Comparative epigenetic analysis of tumour initiating cells and neural stem cells in glioblastoma

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Introduction and findings Glioblastoma (GBM), an aggressive type of brain tumour, is one of the deadliest forms of cancer. Development of effective therapeutic approaches for GBM faces multiple hurdles, including inter- and intra-tumour cellular and transcriptomic heterogeneity. As a result, remnants of tumour can survive by not reacting to anti-cancer drugs. For example, according to

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Single Cell Profiling of the Human Lung – Its Importance in Respiratory Diseases and SARS-CoV-2

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Opinion on Professor Mark Krasnow’s Seminar The lung has millions of gas exchange sites known as alveoli which branch out and interweave with a dense capillary network. Professor Mark Krasnow’s work in profiling human lungs using single cell technology is paving a new path in understanding how our body responds to respiratory diseases and viruses.

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