The study by Lin Gao et al. in Nature Cell Biology examines the effects of SARS-CoV-2 infection on the maternal-fetal interface using single-cell analysis, revealing significant impacts on transcriptomic and epigenomic profiles. This work provides valuable insights into the consequences of the virus on pregnancy.
The study by Lin Gao et al. in Nature Cell Biology examines the effects of SARS-CoV-2 infection on the maternal-fetal interface using single-cell analysis, revealing significant impacts on transcriptomic and epigenomic profiles. This work provides valuable insights into the consequences of the virus on pregnancy.
Xuemeng Zhou, Tsz Wing Sam, Ah Young Lee, Danny Leung. Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations. Nature Communications, 12, Article number: 6462 doi: 10.1126/science.aba5510.1038/s41467-021-26630-z45
Song X*, Aw JTM*, Ma F, Cheung MF, Leung D#, Herrup K.# DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response. J Neurosci. 2021 Sep 28:JN-RM-0845-21. doi:10.1523/JNEUROSCI.0845-21.2021. PMID: 34593604. *co-first authors #co-correspondent authors
Kyle N. Klein, Peiyao A. Zhao, Xiaowen Lyu, Takayo Sasaki, Daniel A. Bartlett, Amar M. Singh, Ipek Tasan, Meng Zhang, Lotte P. Watts, Shin-ichiro Hiraga, Toyoaki Natsume, Xuemeng Zhou, Timour Baslan, Danny Leung, Masato T. Kanemaki, Anne D. Donaldson, Huimin Zhao, Stephen Dalton, Victor G. Corces, David M. Gilbert. Replication timing maintains the global epigenetic state
Sabrina Ka Man Tam, Danny Chi Yeu Leung. Epigenomic and transcriptomic analysis of chronic inflammatory diseases. Genes Genomics, vol. 43, 2021, pp. 227-236, doi: 10.1007/s13258-021-01045-8
Clare S. K. Lee, Ming Fung Cheung, Jinsen Li, Yongqian Zhao, Wai Hei Lam, Vincy Ho, Remo Rohs, Yuanliang Zhai, Danny Leung, Bik-Kwoon Tye. Humanizing the yeast origin recognition complex. Nature Communications, vol. 12, 2021, doi: 10.1038/s41467-020-20277-y
Publication: “Humanizing the yeast origin recognition complex” in Nature communications. Read More »
Qinghong Jiang, Julie Y.J. Ang, Ah Young Lee, Qin Cao, Kelly Y. Li, Kevin Y. Yip, Danny C.Y. Leung. G9a Plays Distinct Roles in Maintaining DNA Methylation, Retrotransposon Silencing, and Chromatin Looping. Cell Reports, vol. 33, 2020, pp. 108315, doi: 10.1016/j.celrep.2020.108315
Qin Cao, Zhenghao Zhang, Alexander Xi Fu, Qiong Wu, Tin-Lap Lee, Eric Lo, Alfred S. L. Cheng, Chao Cheng, Danny Leung, Kevin Y. Yip. A unified framework for integrative study of heterogeneous gene regulatory mechanisms. Nature Machine Intelligence, vol. 2, 2020, pp. 447-456, doi: 10.1038/s42256-020-0205-2
Chin Soon Chee, Danny Leung. Targeting Epigenetic Modifiers for Cancer Treatments. Current Pharmacology Reports, vol. 4, 2018, pp. 193-201, doi: 10.1007/s40495-018-0130-9