Introduction and findings Glioblastoma (GBM), an aggressive type of brain tumour, is one of the deadliest forms of cancer. Development of effective therapeutic approaches for GBM faces multiple hurdles, including inter- and intra-tumour cellular and transcriptomic heterogeneity. As a result, remnants of tumour can survive by not reacting to anti-cancer drugs. For example, according to […]
Opinion on Professor Mark Krasnow’s Seminar The lung has millions of gas exchange sites known as alveoli which branch out and interweave with a dense capillary network. Professor Mark Krasnow’s work in profiling human lungs using single cell technology is paving a new path in understanding how our body responds to respiratory diseases and viruses.
Introduction and Findings The discovery and validation of human transcriptional silencer elements are scarce. The lack of advance techniques and understanding of their characteristics have resulted in only a handful of silencer discoveries for genes such as human synapsin I, BDNF and CD4. This is in contrast to enhancers and “super-enhancers” of the human genome
H3K27me3-rich Regions Function as Silencers Read More »