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Publication: “Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions” in Nature Communications

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The study by Lin Gao et al. in Nature Cell Biology examines the effects of SARS-CoV-2 infection on the maternal-fetal interface using single-cell analysis, revealing significant impacts on transcriptomic and epigenomic profiles. This work provides valuable insights into the consequences of the virus on pregnancy.

Publication: “Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions” in Nature Communications Read More »

Publication: “Single-Cell Analysis Reveals Transcriptomic and Epigenomic Impacts on the Maternal-Fetal Interface Following SARS-CoV-2 Infection” in Nature Cell Biology

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The study by Lin Gao et al. in Nature Cell Biology examines the effects of SARS-CoV-2 infection on the maternal-fetal interface using single-cell analysis, revealing significant impacts on transcriptomic and epigenomic profiles. This work provides valuable insights into the consequences of the virus on pregnancy.

Publication: “Single-Cell Analysis Reveals Transcriptomic and Epigenomic Impacts on the Maternal-Fetal Interface Following SARS-CoV-2 Infection” in Nature Cell Biology Read More »

Publication: “Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations” in Nature Communications

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Xuemeng Zhou, Tsz Wing Sam, Ah Young Lee, Danny Leung. Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations. Nature Communications, 12, Article number: 6462  doi: 10.1126/science.aba5510.1038/s41467-021-26630-z45

Publication: “Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations” in Nature Communications Read More »

Publication: “DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response” in The Journal of Neuroscience

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Song X*, Aw JTM*, Ma F, Cheung MF, Leung D#, Herrup K.# DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response. J Neurosci. 2021 Sep 28:JN-RM-0845-21. doi:10.1523/JNEUROSCI.0845-21.2021. PMID: 34593604. *co-first authors #co-correspondent authors 

Publication: “DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response” in The Journal of Neuroscience Read More »

Publication: “Replication timing maintains the global epigenetic state in human cells” in Science

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Kyle N. Klein, Peiyao A. Zhao, Xiaowen Lyu, Takayo Sasaki, Daniel A. Bartlett, Amar M. Singh, Ipek Tasan, Meng Zhang, Lotte P. Watts, Shin-ichiro Hiraga, Toyoaki Natsume, Xuemeng Zhou, Timour Baslan, Danny Leung, Masato T. Kanemaki, Anne D. Donaldson, Huimin Zhao, Stephen Dalton, Victor G. Corces, David M. Gilbert. Replication timing maintains the global epigenetic state

Publication: “Replication timing maintains the global epigenetic state in human cells” in Science Read More »

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